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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Aldehyde dehydrogenase family 3 member A2

UniprotKB/SwissProt ID: P51648 (P51648)

Gene Name: ALDH3A2

Organism: Homo sapiens (Human)

Function: Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:18035827, PubMed:18182499, PubMed:22633490, PubMed:25047030, PubMed:9133646, PubMed:9662422). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Microsome membrane. Endoplasmic reticulum membrane

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR016161 Ald_DH/histidinol_DH
IPR016163 Ald_DH_C
IPR016160 Ald_DH_CS_CYS
IPR029510 Ald_DH_CS_GLU
IPR016162 Ald_DH_N
IPR015590 Aldehyde_DH_dom
IPR012394 Aldehyde_DH_NAD(P)

The S-nitrosylation sites of P51648

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 214 VTLELGGKSP C YIDKDCDLDI   
2 226 IDKDCDLDIV C RRITWGKYMN   
3 425 SFDTFSHQRP C LLKSLKREGA   
4 50 DILTAIAADL C KSEFNVYSQE