Protein Name:
Glyceraldehyde-3-phosphate dehydrogenase
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UniprotKB/SwissProt ID: P51469 (P51469)
Gene Name:
gapdh
Organism: Xenopus laevis (African clawed frog)
Function: Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P51469
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
150 |
NSLKVVSNAS C TTNCLAPLAK |
CCEEEECCCC H HHHHHHHHHH |
5.17% |
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