UniprotKB/SwissProt ID: P51157 (P51157)
Gene Name:
RAB28
Organism: Homo sapiens (Human)
Function: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:8647132). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:8647132). RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina (By similarity). Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus
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