Protein Name:
RNA-binding protein FXR2
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UniprotKB/SwissProt ID: P51116 (P51116)
Gene Name:
FXR2
Organism: Homo sapiens (Human)
Function: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis (By similarity). Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability (By similarity). Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, Cytoplasmic ribonucleoprotein granule. Cytoplasm. Postsynapse
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P51116
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
109 |
GDFYVIEYAA C DATYNEIVTL |
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| 2 |
270 |
VTAIELGEET C TFRIYGETPE |
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| 3 |
282 |
FRIYGETPEA C RQARSYLEFS |
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| 4 |
87 |
VYSRANEQEP C GWWLARVRMM |
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