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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: T-complex protein 1 subunit delta
UniprotKB/SwissProt ID: P50991 (P50991)

Gene Name: CCT4

Organism: Homo sapiens (Human)

Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR012717 Chap_CCT_delta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/GroEL/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
IPR053374 TCP-1_chaperonin
IPR054827 thermosome_alpha
The S-nitrosylation sites of P50991
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 120 VIIAGSLLDS C TKLLQKGIHP  CCCCCCCCCC C CCCCCCCCCC  3.77%
2 221 VKKLGGTIDD C ELVEGLVLTQ  CCCCCCCCCC C CCCCCCCCCC  3.75%
3 252 EKAKIGLIQF C LSAPKTDMDN  CCCCCCCCCC C CCCCCCCCCC  1.36% 37478858
4 295 NLVKQIKKTG C NVLLIQKSIL  CCCCCCCCCC C CCCCCCCCCC  3.73% 22178444
2212679
20140087
5 337 DIEREDIEFI C KTIGTKPVAH  CCCCCCCCCC C CCCCCCCCCC  3.74%
6 379 GSGKLLKITG C ASPGKTVTIV  CCCCCCCCCC C CCCCCCCCCC  2.25% 22178444
19483679
20140087
7 410 EAERSIHDAL C VIRCLVKKRA  CCCCCCCCCC C CCCCCCCCCC  2.28% 19483679
8 450 SRTLSGMESY C VRAFADAMEV  CCCCCCCCCC C CCCCCCCCCC  2.02%