Protein Name:
T-complex protein 1 subunit theta
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UniprotKB/SwissProt ID: P50990 (P50990)
Gene Name:
CCT8
Organism: Homo sapiens (Human)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P50990
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
136 |
SEVIEGYEIA C RKAHEILPNL |
CCCCCCCCCC H HHHHHHHHHH |
5.87% |
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| 2 |
148 |
KAHEILPNLV C CSAKNLRDID |
CCCCCCCCCC H HHHHHHHHHH |
1.38% |
22178444
19483679
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| 3 |
149 |
AHEILPNLVC C SAKNLRDIDE |
CCCCCCCCCC H HHHHHHHHHH |
3.27% |
22178444
19483679
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| 4 |
244 |
VKDAKIAVYS C PFDGMITETK |
CCCCCCCCCC H HHHHHHHHHH |
1.82% |
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| 5 |
347 |
TPPVLEEMGH C DSVYLSEVGD |
CCCCCCCCCC H HHHHHHHHHH |
3.27% |
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| 6 |
36 |
EEAVYRNIQA C KELAQTTRTA |
CCCCCCCCCC H HHHHHHHHHH |
1.7% |
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| 7 |
430 |
AKQITSYGET C PGLEQYAIKK |
CCCCCCCCCC H HHHHHHHHHH |
1.88% |
19483679
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