Protein Name:
Kinetochore-associated protein 1
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UniprotKB/SwissProt ID: P50748 (P50748)
Gene Name:
KNTC1
Organism: Homo sapiens (Human)
Function: Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores (PubMed:11146660, PubMed:11590237, PubMed:15824131). Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P50748
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
2099 |
HQQIKNFLGS C DPQVILKQLE |
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| 2 |
475 |
IQDDEFVVNY C LKAQWITYET |
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