Protein Name:
Proliferation-associated protein 2G4
|
UniprotKB/SwissProt ID: P50580 (P50580)
Gene Name:
Pa2g4
Organism: Mus musculus (Mouse)
Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly (By similarity). Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Together with PTBP1 is required for the translation initiation on the foot-and-mouth disease virus (FMDV) IRES. Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Nucleus, nucleolus. Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P50580
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
149 |
KADVIKAAHL C AEAALRLVKP |
CCCCHHHHHH H HHHHHHHEEE |
2% |
|
| 2 |
179 |
AWNKVAHSFN C TPIEGMLSHQ |
CCCCHHHHHH H HHHHHHHEEE |
4.51% |
|
| 3 |
49 |
SSSGVSVLSL C EKGDAMIMEE |
CCCCHHHHHH H HHHHHHHEEE |
4.57% |
24926564
|
|
