Protein Name:
Methionine aminopeptidase 2
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UniprotKB/SwissProt ID: P50579 (P50579)
Gene Name:
METAP2
Organism: Homo sapiens (Human)
Function: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P50579
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
121 |
VQTDPPSVPI C DLYPNGVFPK |
CCCHHCHHCC C CCCCCCCCHH |
11.02% |
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| 2 |
135 |
PNGVFPKGQE C EYPPTQDGRT |
CCCHHCHHCC C CCCCCCCCHH |
63.74% |
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| 3 |
298 |
IKCAGIDVRL C DVGEAIQEVM |
CCCHHCHHCC C CCCCCCCCHH |
11.36% |
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| 4 |
380 |
GKGVVHDDME C SHYMKNFDVG |
CCCHHCHHCC C CCCCCCCCHH |
18.62% |
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| 5 |
416 |
INENFGTLAF C RRWLDRLGES |
CCCHHCHHCC C CCCCCCCCHH |
40.46% |
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| 6 |
436 |
SKYLMALKNL C DLGIVDPYPP |
CCCHHCHHCC C CCCCCCCCHH |
45.81% |
19483679
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| 7 |
448 |
LGIVDPYPPL C DIKGSYTAQF |
CCCHHCHHCC C CCCCCCCCHH |
32.42% |
19483679
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| 8 |
468 |
FEHTILLRPT C KEVVSRGDDY |
CCCHHCHHCC C CCCCCCCCHH |
54.33% |
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