Protein Name:
V-type proton ATPase catalytic subunit A
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UniprotKB/SwissProt ID: P50516 (P50516)
Gene Name:
Atp6v1a
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:23863464). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). May play a role in neurite development and synaptic connectivity (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytosol. Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Lysosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P50516
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
240 |
GQRVLDALFP C VQGGTTAIPG |
CCHHHCCCCC C CCCCCCCCCC |
2.53% |
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| 2 |
254 |
GTTAIPGAFG C GKTVISQSLS |
CCHHHCCCCC C CCCCCCCCCC |
4% |
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| 3 |
532 |
QNGYTPYDRF C PFYKTVGMLS |
CCHHHCCCCC C CCCCCCCCCC |
2.07% |
24895380
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