Protein Name:
Cysteine and glycine-rich protein 3
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UniprotKB/SwissProt ID: P50462 (P50462)
Gene Name:
Csrp3
Organism: Mus musculus (Mouse)
Function: Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (By similarity). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation (PubMed:15665106, PubMed:9039266). The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association (By similarity). In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (PubMed:27353086)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Cytoplasm, myofibril, sarcomere
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P50462
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
120 |
FSAKFGESEK C PRCGKSVYAA |
CCCCCCCCCC C CCCCEEEECC |
1.95% |
21278135
|
| 2 |
123 |
KFGESEKCPR C GKSVYAAEKV |
CCCCCCCCCC C CCCCEEEECC |
4.93% |
21278135
|
| 3 |
168 |
NVTDKDGELY C KVCYAKNFGP |
CCCCCCCCCC C CCCCEEEECC |
4.1% |
21278135
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| 4 |
171 |
DKDGELYCKV C YAKNFGPTGI |
CCCCCCCCCC C CCCCEEEECC |
1.35% |
21278135
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| 5 |
25 |
KTVYHAEEIQ C NGRSFHKTCF |
CCCCCCCCCC C CCCCEEEECC |
7.77% |
21278135
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| 6 |
37 |
GRSFHKTCFH C MACRKALDST |
CCCCCCCCCC C CCCCEEEECC |
0.65% |
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| 7 |
40 |
FHKTCFHCMA C RKALDSTTVA |
CCCCCCCCCC C CCCCEEEECC |
1.5% |
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| 8 |
58 |
TVAAHESEIY C KVCYGRRYGP |
CCCCCCCCCC C CCCCEEEECC |
3.06% |
21278135
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| 9 |
79 |
KGIGFGQGAG C LSTDTGEHLG |
CCCCCCCCCC C CCCCEEEECC |
2.41% |
21278135
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