Protein Name:
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
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UniprotKB/SwissProt ID: P50213 (P50213)
Gene Name:
IDH3A
Organism: Homo sapiens (Human)
Function: Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P50213
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
127 |
TFDLYANVRP C VSIEGYKTPY |
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| 2 |
215 |
RMSDGLFLQK C REVAESCKDI |
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| 3 |
222 |
LQKCREVAES C KDIKFNEMYL |
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| 4 |
331 |
FDHAARIEAA C FATIKDGKSL |
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| 5 |
359 |
AKCSDFTEEI C RRVKDLD--- |
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