UniprotKB/SwissProt ID: P49961 (P49961)
Gene Name:
ENTPD1
Organism: Homo sapiens (Human)
Function: Catalyzes the hydrolysis of both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates and participates in the regulation of extracellular levels of nucleotides (Probable) (PubMed:8529670, PubMed:8626624, PubMed:8955160, PubMed:8996251). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (PubMed:8955160, PubMed:8996251)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane. Membrane, caveola
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