Protein Name:
DNA ligase 3
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UniprotKB/SwissProt ID: P49916 (P49916)
Gene Name:
LIG3
Organism: Homo sapiens (Human)
Function: Isoform 3 functions as a heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as a DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion. Mitochondrion. Nucleus. Nucleus
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P49916
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
336 |
IVKLFSRIFN C NPDDMARDLE |
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| 2 |
929 |
EKRKAADETL C QTKVLLDIFT |
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| 3 |
94 |
GPCEMAEQRF C VDYAKRGTAG |
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