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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: GMP synthase [glutamine-hydrolyzing]

UniprotKB/SwissProt ID: P49915 (P49915)

Gene Name: GMPS

Organism: Homo sapiens (Human)

Function: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm, cytosol

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029062 Class_I_gatase-like
IPR017926 GATASE
IPR001674 GMP_synth_C
IPR004739 GMP_synth_GATase
IPR025777 GMPS_ATP_PPase_dom
IPR022310 NAD/GMP_synthase
IPR014729 Rossmann-like_a/b/a_fold

The S-nitrosylation sites of P49915

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 137 GVFNISVDNT C SLFRGLQKEE  CCCCCCCCCC C CCCCCCCCCC  4.11%
2 213 LKNFLYDIAG C SGTFTVQNRE  CCCCCCCCCC C CCCCCCCCCC  2.21%
3 449 PGPGLAIRVI C AEEPYICKDF  CCCCCCCCCC C CCCCCCCCCC  3.4% 19483679
4 456 RVICAEEPYI C KDFPETNNIL  CCCCCCCCCC C CCCCCCCCCC  2.6% 19483679
5 489 PHTLLQRVKA C TTEEDQEKLM  CCCCCCCCCC C CCCCCCCCCC  3.92%
6 523 PIKTVGVQGD C RSYSYVCGIS  CCCCCCCCCC C CCCCCCCCCC  3.88%
7 530 QGDCRSYSYV C GISSKDEPDW  CCCCCCCCCC C CCCCCCCCCC  2.81%