Protein Name:
E3 SUMO-protein ligase RanBP2
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UniprotKB/SwissProt ID: P49792 (P49792)
Gene Name:
RANBP2
Organism: Homo sapiens (Human)
Function: E3 SUMO-protein ligase which facilitates SUMO1 and SUMO2 conjugation by UBE2I (PubMed:11792325, PubMed:12032081, PubMed:15378033, PubMed:15931224, PubMed:22194619). Involved in transport factor (Ran-GTP, karyopherin)-mediated protein import via the F-G repeat-containing domain which acts as a docking site for substrates (PubMed:7775481). Binds single-stranded RNA (in vitro) (PubMed:7775481). May bind DNA (PubMed:7775481). Component of the nuclear export pathway (PubMed:10078529). Specific docking site for the nuclear export factor exportin-1 (PubMed:10078529). Inhibits EIF4E-dependent mRNA export (PubMed:22902403). Sumoylates PML at 'Lys-490' which is essential for the proper assembly of PML-NB (PubMed:22155184). Recruits BICD2 to the nuclear envelope and cytoplasmic stacks of nuclear pore complex known as annulate lamellae during G2 phase of cell cycle (PubMed:20386726). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357, PubMed:23353830)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Nucleus membrane. Nucleus, nuclear pore complex. Nucleus envelope
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P49792
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
105 |
DLVLKIAELL C KNDVTDGRAK |
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| 2 |
1196 |
TGEEDEEEFF C NRAKLFRFDV |
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| 3 |
1335 |
EPTSHDNKDI C KSDAGNLNFE |
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| 4 |
1375 |
NASTAKKCVS C QNLNPSNKEL |
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| 5 |
1438 |
NEPTVSRCIA C QNTKSANKSG |
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| 6 |
1488 |
TKEGQWDCSA C LVQNEGSSTK |
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| 7 |
1747 |
NEASATKCIA C QCPSKQNQTT |
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| 8 |
1791 |
RKGQWDCSVC C VQNESSSLKC |
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| 9 |
206 |
ALRSSLEWNS C VVQTLKEYLE |
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| 10 |
2084 |
LMRREQVLKV C ANHWITTTMN |
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| 11 |
220 |
TLKEYLESLQ C LESDKSDWRA |
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| 12 |
2407 |
GTERVWLWTA C DFADGERKVE |
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| 13 |
2696 |
GKLYLDGSEK C RPLEENTADN |
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| 14 |
2791 |
GGTEVMVPSF C KSEEPDSITK |
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| 15 |
3040 |
ADCFKKTFEE C QQNLMKLQKG |
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| 16 |
3071 |
ETNPVVFFDV C ADGEPLGRIT |
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| 17 |
3122 |
IFHRVIPDFV C QGGDITKHDG |
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| 18 |
3221 |
SVCRRITITE C GQI------- |
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| 19 |
348 |
AGQNLLEMMA C DRLSQSGHML |
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| 20 |
50 |
KEYDLAKKYI C TYINVQERDP |
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| 21 |
536 |
ERQKSWWDAV C TLIHRKAVPG |
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| 22 |
581 |
QPALLVHWAE C LQKTGSGLNS |
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| 23 |
707 |
DALSPEEQEE C KNYLRKTRDY |
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