Protein Name:
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
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UniprotKB/SwissProt ID: P49748 (P49748)
Gene Name:
ACADVL
Organism: Homo sapiens (Human)
Function: Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9599005, PubMed:9839948). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:18227065, PubMed:7668252, PubMed:9461620, PubMed:9839948). Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains (PubMed:21237683, PubMed:9839948)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion inner membrane. Mitochondrion inner membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P49748
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
156 |
VPSELGGVGL C NTQYARLVEI |
CHHHHHHHHH H HHHHHCCCCH |
4.21% |
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| 2 |
215 |
LASGETVAAF C LTEPSSGSDA |
CHHHHHHHHH H HHHHHCCCCH |
3.84% |
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| 3 |
237 |
SIRTSAVPSP C GKYYTLNGSK |
CHHHHHHHHH H HHHHHCCCCH |
9.6% |
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| 4 |
603 |
HPTAQHEKML C DTWCIEAAAR |
CHHHHHHHHH H HHHHHCCCCH |
3.81% |
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