Protein Name:
DNA replication licensing factor MCM2
|
UniprotKB/SwissProt ID: P49736 (P49736)
Gene Name:
MCM2
Organism: Homo sapiens (Human)
Function: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (PubMed:8175912). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (PubMed:26196677)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P49736
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
315 |
LIRTSGVVTS C TGVLPQLSMV |
|
|
|
| 2 |
522 |
KVRGDINVLL C GDPGTAKSQF |
|
|
|
| 3 |
584 |
GALVLADRGV C LIDEFDKMND |
|
|
|
| 4 |
624 |
AGIVTSLQAR C TVIAAANPIG |
|
|
|
| 5 |
661 |
EPIISRFDIL C VVRDTVDPVQ |
|
|
|
|
