Protein Name:
Centromere protein F
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UniprotKB/SwissProt ID: P49454 (P49454)
Gene Name:
CENPF
Organism: Homo sapiens (Human)
Function: Required for kinetochore function and chromosome segregation in mitosis. Required for kinetochore localization of dynein, LIS1, NDE1 and NDEL1. Regulates recycling of the plasma membrane by acting as a link between recycling vesicles and the microtubule network though its association with STX4 and SNAP25. Acts as a potential inhibitor of pocket protein-mediated cellular processes during development by regulating the activity of RB proteins during cell division and proliferation. May play a regulatory or permissive role in the normal embryonic cardiomyocyte cell cycle and in promoting continued mitosis in transformed, abnormally dividing neonatal cardiomyocytes. Interaction with RB directs embryonic stem cells toward a cardiac lineage. Involved in the regulation of DNA synthesis and hence cell cycle progression, via its C-terminus. Has a potential role regulating skeletal myogenesis and in cell differentiation in embryogenesis. Involved in dendritic cell regulation of T-cell immunity against chlamydia
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, perinuclear region. Nucleus matrix. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P49454
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1029 |
KQEKLILLQR C EETGNAYEDL |
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| 2 |
1166 |
LMKVMKTKHE C QNLESEPIRN |
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| 3 |
142 |
AQSADVSLNP C NTPQKIFTTP |
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| 4 |
1480 |
EGLVPSLSSS C VPDSSSLSSL |
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| 5 |
1556 |
AKGVEELESL C EVYRQSLEKL |
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| 6 |
1597 |
LLSSERQELD C LRKQYLSENE |
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| 7 |
1721 |
ETGAVKPTGE C SGEQSPDTNY |
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| 8 |
2464 |
VAALHNDQEA C KAKEQNLSSQ |
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| 9 |
383 |
CQRQNAESAR C SLEQKIKEKE |
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| 10 |
569 |
AVADLEKQRD C SQDLLKKREH |
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| 11 |
752 |
LSNEIMDKDR C YQDLHAEYES |
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| 12 |
76 |
KRENQRLMEI C ESLEKTKQKI |
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