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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Elongation factor Tu, mitochondrial
UniprotKB/SwissProt ID: P49411 (P49411)

Gene Name: TUFM

Organism: Homo sapiens (Human)

Function: GTP hydrolase that promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Also plays a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIGI-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR041709 EF-Tu_GTP-bd
IPR050055 EF-Tu_GTPase
IPR004161 EFTu-like_2
IPR033720 EFTU_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 T_Tr_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004541 Transl_elong_EFTu/EF1A_bac/org
IPR004160 Transl_elong_EFTu/EF1A_C
The S-nitrosylation sites of P49411
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 130 TAARHYAHTD C PGHADYVKNM  CCHHHHHHHC C CCCCCCCHHH  10.69%
2 150 MITGTAPLDG C ILVVAANDGP  CCHHHHHHHC C CCCCCCCHHH  1.08%
3 225 ETPVIVGSAL C ALEGRDPELG  CCHHHHHHHC C CCCCCCCHHH  33.39%
4 293 ERGILKKGDE C ELLGHSKNIR  CCHHHHHHHC C CCCCCCCHHH  2.43% 22178444
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