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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: T-complex protein 1 subunit gamma
UniprotKB/SwissProt ID: P49368 (P49368)

Gene Name: CCT3

Organism: Homo sapiens (Human)

Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR012719 Chap_CCT_gamma
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/GroEL/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
IPR053374 TCP-1_chaperonin
IPR054827 thermosome_alpha
The S-nitrosylation sites of P49368
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 173 KAISRWSSLA C NIALDAVKMV  CCCCCCEEEE E CCCCCCCCCC  4.61% 22178444
19483679
2 213 KIPGGIIEDS C VLRGVMINKD  CCCCCCEEEE E CCCCCCCCCC  5.31% 22178444
19483679
3 366 GDEYFTFITD C KDPKACTILL  CCCCCCEEEE E CCCCCCCCCC  3.94%
4 372 FITDCKDPKA C TILLRGASKE  CCCCCCEEEE E CCCCCCCCCC  2.8%
5 398 ERNLQDAMQV C RNVLLDPQLV  CCCCCCEEEE E CCCCCCCCCC  1.15%
6 40 AKTIADIIRT C LGPKSMMKML  CCCCCCEEEE E CCCCCCCCCC  2.72%
7 455 EVIPRTLIQN C GASTIRLLTS  CCCCCCEEEE E CCCCCCCCCC  2.49%
8 475 SLRAKHTQEN C ETWGVNGETG  CCCCCCEEEE E CCCCCCCCCC  4.92%