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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Fatty acid synthase
UniprotKB/SwissProt ID: P49327 (P49327)

Gene Name: FASN

Organism: Homo sapiens (Human)

Function: Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain (Microbial infection) Fatty acid synthetase activity is required for SARS coronavirus-2/SARS-CoV-2 replication

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Melanosome

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR029058 AB_hydrolase_fold
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase_dom
IPR016035 Acyl_Trfase/lysoPLipase
IPR013149 ADH-like_C
IPR049391 FAS_pseudo-KR
IPR011032 GroES-like_sf
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR016036 Malonyl_transacylase_ACP-bd
IPR013217 Methyltransf_12
IPR036291 NAD(P)-bd_dom_sf
IPR032821 PKS_assoc
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR042104 PKS_dehydratase_sf
IPR020807 PKS_DH
IPR049552 PKS_DH_N
IPR020843 PKS_ER
IPR013968 PKS_KR
IPR049900 PKS_mFAS_DH
IPR050091 PKS_NRPS_Biosynth_Enz
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR006162 Ppantetheine_attach_site
IPR029063 SAM-dependent_MTases_sf
IPR001031 Thioesterase
IPR016039 Thiolase-like
The S-nitrosylation sites of P49327
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 1118 EQQVPILEKF C FTPHTEEGCL  CCEEEEECCC C CCCCCCCHHH  5.71% 19483679
37478858
2 1127 FCFTPHTEEG C LSERAALQEE  CCEEEEECCC C CCCCCCCHHH  4.23% 19483679
37478858
3 1141 RAALQEELQL C KGLVQALQTK  CCEEEEECCC C CCCCCCCHHH  1.8%
4 1186 QELPRLLSAA C RLQLNGNLQL  CCEEEEECCC C CCCCCCCHHH  4.45%
5 1227 GLLDSPALKA C LDTAVENMPS  CCEEEEECCC C CCCCCCCHHH  3.18%
6 135 ETLVGYSMVG C QRAMMANRLS  CCEEEEECCC C CCCCCCCHHH  1.36%
7 1403 KSFYGSTLFL C RRPTPQDSPI  CCEEEEECCC C CCCCCCCHHH  2.44%
8 1448 SRPVWLKAIN C ATSGVVGLVN  CCEEEEECCC C CCCCCCCHHH  3.41% 37478858
9 1459 ATSGVVGLVN C LRREPGGNRL  CCEEEEECCC C CCCCCCCHHH  2.14% 37478858
10 1471 RREPGGNRLR C VLLSNLSSTS  CCEEEEECCC C CCCCCCCHHH  2.75% 22178444
18335467
26851298
37478858
11 1548 RGDLSSIRWV C SSLRHAQPTC  CCEEEEECCC C CCCCCCCHHH  1.49%
12 1558 CSSLRHAQPT C PGAQLCTVYY  CCEEEEECCC C CCCCCCCHHH  3.58%
13 1564 AQPTCPGAQL C TVYYASLNFR  CCEEEEECCC C CCCCCCCHHH  1.28%
14 1759 AEEKLQASVR C LATHGRFLEI  CCEEEEECCC C CCCCCCCHHH  2.58%
15 1828 IRDGVVRPLK C TVFHGAQVED  CCEEEEECCC C CCCCCCCHHH  5.3% 37478858
16 1881 KLMSAISKTF C PAHKSYIIAG  CCEEEEECCC C CCCCCCCHHH  3.35%
17 1992 NQTPEFFQDV C KPKYSGTLNL  CCEEEEECCC C CCCCCCCHHH  9.33%
18 2024 DYFVVFSSVS C GRGNAGQSNY  CCEEEEECCC C CCCCCCCHHH  3.95%
19 2091 SGTLPQRMAS C LEVLDLFLNQ  CCEEEEECCC C CCCCCCCHHH  2.46% 26851298
20 212 RLGMLSPEGT C KAFDTAGNGY  CCEEEEECCC C CCCCCCCHHH  4.38% 2212679
21 2202 SKADEASELA C PTPKEDGLAQ  CCEEEEECCC C CCCCCCCHHH  6.36% 2212679
22 223 KAFDTAGNGY C RSEGVVAVLL  CCEEEEECCC C CCCCCCCHHH  4.01%
23 2273 RLSIPTYGLQ C TRAAPLDSIH  CCEEEEECCC C CCCCCCCHHH  3.15% 37478858
24 2292 IHSLAAYYID C IRQVQPEGPY  CCEEEEECCC C CCCCCCCHHH  1.68%
25 2359 QSYRAKLTPG C EAEAETEAIC  CCEEEEECCC C CCCCCCCHHH  4.76%
26 2369 CEAEAETEAI C FFVQQFTDME  CCEEEEECCC C CCCCCCCHHH  2.53%
27 2468 LGADYNLSQV C DGKVSVHVIE  CCEEEEECCC C CCCCCCCHHH  4.41%
28 313 QELNGITRAL C ATRQEPLLIG  CCEEEEECCC C CCCCCCCHHH  3.38%
29 496 PAGERPLWFI C SGMGTQWRGM  CCEEEEECCC C CCCCCCCHHH  1.78%
30 630 MAAVGLSWEE C KQRCPPGVVP  CCEEEEECCC C CCCCCCCHHH  2.85%
31 634 GLSWEECKQR C PPGVVPACHN  CCEEEEECCC C CCCCCCCHHH  4.4% 19483679
37478858
32 642 QRCPPGVVPA C HNSKDTVTIS  CCEEEEECCC C CCCCCCCHHH  2.27% 19483679
37478858