Protein Name:
Heterogeneous nuclear ribonucleoprotein A1
|
UniprotKB/SwissProt ID: P49312 (P49312)
Gene Name:
Hnrnpa1
Organism: Mus musculus (Mouse)
Function: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1. May bind to specific miRNA hairpins
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
|
|
|
Graphical Visualization of S-nitrosylation Sites:
|
|
The S-nitrosylation sites of P49312
|
| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
175 |
QKYHTVNGHN C EVRKALSKQE |
CCCCCCCCCH H HHHHHHHCCC |
4.19% |
20925432
21278135
|
| 2 |
43 |
HFEQWGTLTD C VVMRDPNTKR |
CCCCCCCCCH H HHHHHHHCCC |
1.78% |
20925432
|
|
