UniprotKB/SwissProt ID: P49282 (P49282)
Gene Name:
Slc11a2
Organism: Mus musculus (Mouse)
Function: Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:16475818). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (By similarity) (PubMed:16475818). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (PubMed:11739192). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity). Can mediate uncoupled fluxes of either protons or metal ions
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Golgi apparatus, trans-Golgi network membrane. Early endosome membrane. Recycling endosome membrane. Cell membrane. Golgi apparatus, trans-Golgi network membrane. Early endosome membrane. Late endosome membrane. Lysosome membrane. Cell membrane. Apical cell membrane. Mitochondrion outer membrane. Extracellular vesicle membrane
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