UniprotKB/SwissProt ID: P49281 (P49281)
Gene Name:
SLC11A2
Organism: Homo sapiens (Human)
Function: Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity) (PubMed:24448823). Can mediate uncoupled fluxes of either protons or metal ions
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Early endosome membrane. Apical cell membrane. Late endosome membrane. Lysosome membrane. Apical cell membrane. Cell membrane. Extracellular vesicle membrane. Cell membrane. Mitochondrion outer membrane. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane
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