Protein Name:
T-complex protein 1 subunit epsilon
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UniprotKB/SwissProt ID: P48643 (P48643)
Gene Name:
CCT5
Organism: Homo sapiens (Human)
Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P48643
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
181 |
TTLGSKVVNS C HRQMAEIAVN |
CCCCCCEEEC C CCCEEEEEEC |
2.3% |
19483679
37478858
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| 2 |
253 |
VEDAKIAILT C PFEPPKPKTK |
CCCCCCEEEC C CCCEEEEEEC |
3.05% |
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| 3 |
302 |
IKETGANLAI C QWGFDDEANH |
CCCCCCEEEC C CCCEEEEEEC |
2.01% |
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| 4 |
377 |
TKDKMLVIEQ C KNSRAVTIFI |
CCCCCCEEEC C CCCEEEEEEC |
2.67% |
2212679
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| 5 |
407 |
EAKRSLHDAL C VIRNLIRDNR |
CCCCCCEEEC C CCCEEEEEEC |
2.28% |
19483679
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| 6 |
429 |
VYGGGAAEIS C ALAVSQEADK |
CCCCCCEEEC C CCCEEEEEEC |
4.4% |
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| 7 |
440 |
ALAVSQEADK C PTLEQYAMRA |
CCCCCCEEEC C CCCEEEEEEC |
2.99% |
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| 8 |
493 |
KEMNPALGID C LHKGTNDMKQ |
CCCCCCEEEC C CCCEEEEEEC |
3.97% |
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