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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Glutamate--cysteine ligase catalytic subunit

UniprotKB/SwissProt ID: P48506 (P48506)

Gene Name: GCLC

Organism: Homo sapiens (Human)

Function: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization:

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR004308 GCS
IPR014746 Gln_synth/guanido_kin_cat_dom

The S-nitrosylation sites of P48506

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 142 TSILEENQAL C TITSFPRLGC   
2 295 FYRGYVSDID C RWGVISASVD   
3 501 CKGGNAVVDG C GKAQNSTELA