Protein Name:
Lanosterol synthase
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UniprotKB/SwissProt ID: P48449 (P48449)
Gene Name:
LSS
Organism: Homo sapiens (Human)
Function: Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:14766201, PubMed:26200341, PubMed:7639730). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (PubMed:26200341)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P48449
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
616 |
GTACAEVSRA C DFLLSRQMAD |
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| 2 |
636 |
DGGWGEDFES C EERRYLQSAQ |
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