UniprotKB/SwissProt ID: P48379 (P48379)
Gene Name:
Rfx2
Organism: Mus musculus (Mouse)
Function: Transcription factor that acts as a key regulator of spermatogenesis (PubMed:26162102, PubMed:26248850, PubMed:26853561). Acts by regulating expression of genes required for the haploid phase during spermiogenesis, such as genes required for cilium assembly and function (PubMed:26162102, PubMed:26853561). Recognizes and binds the X-box, a regulatory motif with DNA sequence 5'-GTNRCC(0-3N)RGYAAC-3' present on promoters (PubMed:15229132, PubMed:26162102). Probably activates transcription of the testis-specific histone gene H1-6 (PubMed:15229132)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm
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