Protein Name:
Iron-responsive element-binding protein 2
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UniprotKB/SwissProt ID: P48200 (P48200)
Gene Name:
IREB2
Organism: Homo sapiens (Human)
Function: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P48200
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
137 |
DHSLQIDFSK C AIQNAPNPGG |
CCCCCHHHHH H HHHHHCCCCC |
3.8% |
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| 2 |
178 |
CRGQTTCRGS C DSGELGRNSG |
CCCCCHHHHH H HHHHHCCCCC |
5.56% |
22178444
16479012
15688001
14673166
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