UniprotKB/SwissProt ID: P48148 (P48148)
Gene Name:
Rho1
Organism: Drosophila melanogaster (Fruit fly)
Function: Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan (PubMed:10556060, PubMed:24535826, PubMed:25739458). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10323867, PubMed:10556060). During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm (PubMed:24535826). During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). May have a role in eye development (PubMed:7835340). Involved in targeted recruitment of dia/diaphanous to apical membranes of polarized epithelial cells (PubMed:23853710)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane. Cytoplasm, cytoskeleton. Apical cell membrane. Lateral cell membrane
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