UniprotKB/SwissProt ID: P47931 (P47931)
Gene Name:
Fst
Organism: Mus musculus (Mouse)
Function: Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs) (PubMed:7885475, PubMed:20810712). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (By similarity). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (PubMed:22711699, PubMed:20810712). Also promotes neural differentiation by antagonizing the action BMP4 (PubMed:9178255). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Secreted. Nucleus, nucleolus
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