Protein Name:
Sphingosine 1-phosphate receptor 2
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UniprotKB/SwissProt ID: P47752 (P47752)
Gene Name:
S1pr2
Organism: Rattus norvegicus (Rat)
Function: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10383399). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10383399). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (PubMed:29453251). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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