Protein Name:
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A
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UniprotKB/SwissProt ID: P46978 (P46978)
Gene Name:
Stt3a
Organism: Mus musculus (Mouse)
Function: Catalytic subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. This subunit contains the active site and the acceptor peptide and donor lipid-linked oligosaccharide (LLO) binding pockets. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient post-translational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. STT3A-containing OST-A complex is also required to prevent hyperglycosylation of some target proteins by preventing glycosylation of facultative sites before folding of target proteins is completed
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Endoplasmic reticulum. Endoplasmic reticulum membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P46978
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
637 |
DREGSPVLLN C LMYKMCYYRF |
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