Protein Name:
Microtubule-associated protein 1B
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UniprotKB/SwissProt ID: P46821 (P46821)
Gene Name:
MAP1B
Organism: Homo sapiens (Human)
Function: Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm, cytoskeleton. Cytoplasm. Synapse. Cell projection, dendritic spine. Cytoplasm
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P46821
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
1814 |
TSAVKEKTAT C HSSSSPPIDA |
CCEEEEEECC C CCCCCCCCCC |
2.44% |
2212679
37478858
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| 2 |
190 |
PANKASLTLF C PEEGDWKNSN |
CCEEEEEECC C CCCCCCCCCC |
4.69% |
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| 3 |
2041 |
TTRTPDTSTY C YETAEKITRT |
CCEEEEEECC C CCCCCCCCCC |
2.22% |
37478858
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| 4 |
2065 |
STYSYETSDL C YTAEKKSPSE |
CCEEEEEECC C CCCCCCCCCC |
3.22% |
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| 5 |
2083 |
PSEARQDVDL C LVSSCEYKHP |
CCEEEEEECC C CCCCCCCCCC |
2.82% |
37478858
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| 6 |
2088 |
QDVDLCLVSS C EYKHPKTELS |
CCEEEEEECC C CCCCCCCCCC |
5.29% |
37478858
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| 7 |
2361 |
PPGLPVYLDL C YIPNHSNSKN |
CCEEEEEECC C CCCCCCCCCC |
2.63% |
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| 8 |
2464 |
VVMQDESFPA C KIEL------ |
CCEEEEEECC C CCCCCCCCCC |
4.67% |
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| 9 |
382 |
IKMKRSIEEA C FTLQYLNKLS |
CCEEEEEECC C CCCCCCCCCC |
2.79% |
37478858
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| 10 |
905 |
GITTTEGEGE C EQTPEELEPV |
CCEEEEEECC C CCCCCCCCCC |
7.45% |
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