Protein Name:
Cyclin-dependent kinase inhibitor 1B
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UniprotKB/SwissProt ID: P46527 (P46527)
Gene Name:
CDKN1B
Organism: Homo sapiens (Human)
Function: Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichometry
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Endosome
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P46527
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
148 |
SDSQTGLAEQ C AGIRKRPATD |
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