dbSNO 2.0

Latest news:

Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

Protein Name: Vesicle-fusing ATPase

UniprotKB/SwissProt ID: P46459 (P46459)

Gene Name: NSF

Organism: Homo sapiens (Human)

Function: Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. Interaction with AMPAR subunit GRIA2 leads to influence GRIA2 membrane cycling (By similarity)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm

Graphical Visualization of S-nitrosylation Sites:

InterPro ID	Domain Name
IPR003593	AAA+_ATPase
IPR041569	AAA_lid_3
IPR009010	Asp_de-COase-like_dom_sf
IPR003959	ATPase_AAA_core
IPR003960	ATPase_AAA_CS
IPR004201	Cdc48_dom2
IPR029067	CDC48_domain_2-like_sf
IPR003338	CDC4_N-term_subdom
IPR054419	NSF_ATPase_lid
IPR027417	P-loop_NTPase
IPR039812	Vesicle-fus_ATPase

The S-nitrosylation sites of P46459

No.	Position	S-nitrosylated Peptide	Secondary Structure of S-nitrosylated Peptide	Solvent Accessibility of nitrosylated Site	PubMed ID
1	11	MAGRSMQAAR C PTDELSLTNC	CCCCCCCCCC C CCCCCCCCCE	3.5%
2	21	CPTDELSLTN C AVVNEKDFQS	CCCCCCCCCC C CCCCCCCCCE	2.27%	22178444 14567912
3	250	FPPEIVEQMG C KHVKGILLYG	CCCCCCCCCC C CCCCCCCCCE	2.01%	22178444 16418269
4	264	KGILLYGPPG C GKTLLARQIG	CCCCCCCCCC C CCCCCCCCCE	6.61%	22178444 24105792 14567912
5	334	IIIFDEIDAI C KQRGSMAGST	CCCCCCCCCC C CCCCCCCCCE	3.09%
6	599	FDDAYKSQLS C VVVDDIERLL	CCCCCCCCCC C CCCCCCCCCE	3.51%
7	91	SLYTFDKAKQ C IGTMTIEIDF	CCCCCCCCCC C CCCCCCCCCE	2.82%	22178444 15944123 14567912

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