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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Translation initiation factor IF-2, mitochondrial

UniprotKB/SwissProt ID: P46199 (P46199)

Gene Name: MTIF2

Organism: Homo sapiens (Human)

Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Mitochondrion

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR053905 EF-G-like_DII
IPR044145 IF2_II
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd
IPR000795 T_Tr_GTP-bd_dom
IPR000178 TF_IF2_bacterial-like
IPR015760 TIF_IF2
IPR023115 TIF_IF2_dom3
IPR036925 TIF_IF2_dom3_sf
IPR009000 Transl_B-barrel_sf

The S-nitrosylation sites of P46199

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 692 DISIVKTGMD C GLSLDEDNME   
2 711 MEFQVGDRIV C YEEKQIQAKT