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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Ran GTPase-activating protein 1
UniprotKB/SwissProt ID: P46060 (P46060)

Gene Name: RANGAP1

Organism: Homo sapiens (Human)

Function: GTPase activator for RAN (PubMed:16428860, PubMed:8146159, PubMed:8896452). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is essential for RAN-mediated nuclear import and export (PubMed:27160050, PubMed:8896452). Mediates dissociation of cargo from nuclear export complexes containing XPO1, RAN and RANBP2 after nuclear export (PubMed:27160050)

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Cytoplasm. Nucleus, nucleoplasm. Nucleus envelope. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR001611 Leu-rich_rpt
IPR032675 LRR_dom_sf
IPR009109 Ran_GTPase_activating_1_C
IPR027038 RanGap
IPR036720 RanGAP1_C_sf
The S-nitrosylation sites of P46060
No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 141 GFEALLKSSA C FTLQELKLNN  CCHHHHHHHH H HHHHHCCCCC  2.64%
2 152 FTLQELKLNN C GMGIGGGKIL  CCHHHHHHHH H HHHHHCCCCC  3.75%
3 169 GKILAAALTE C HRKSSAQGKP  CCHHHHHHHH H HHHHHCCCCC  2.95% 19483679
4 274 RQVEVINFGD C LVRSKGAVAI  CCHHHHHHHH H HHHHHCCCCC  3.76%
5 303 PKLKELNLSF C EIKRDAALAV  CCHHHHHHHH H HHHHHCCCCC  4.8%
6 338 LNGNTLGEEG C EQLQEVLEGF  CCHHHHHHHH H HHHHHCCCCC  3.22%
7 573 VTKPNSALES C SFARHSLLQT  CCHHHHHHHH H HHHHHCCCCC  2.57%
8 82 ALEKKSELKR C HWSDMFTGRL  CCHHHHHHHH H HHHHHCCCCC  3.54%