Protein Name:
Chromobox protein homolog 5
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UniprotKB/SwissProt ID: P45973 (P45973)
Gene Name:
CBX5
Organism: Homo sapiens (Human)
Function: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Chromosome. Chromosome, centromere
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P45973
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
133 |
PEKIIGATDS C GDLMFLMKWK |
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| 2 |
160 |
LVLAKEANVK C PQIVIAFYEE |
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| 3 |
59 |
NTWEPEKNLD C PELISEFMKK |
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