Protein Name:
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
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UniprotKB/SwissProt ID: P45952 (P45952)
Gene Name:
Acadm
Organism: Mus musculus (Mouse)
Function: Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:16121256). The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (PubMed:16121256). Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains (PubMed:16121256)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P45952
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
156 |
LGRMTEQPMM C AYCVTEPSAG |
CHHHHHHHCH H HHHCCCCCCC |
1.66% |
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| 2 |
159 |
MTEQPMMCAY C VTEPSAGSDV |
CHHHHHHHCH H HHHCCCCCCC |
1.3% |
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| 3 |
244 |
GKKELNMGQR C SDTRGIAFED |
CHHHHHHHCH H HHHCCCCCCC |
3.12% |
21278135
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