Protein Name:
Non-selective voltage-gated ion channel VDAC2
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UniprotKB/SwissProt ID: P45880 (P45880)
Gene Name:
VDAC2
Organism: Homo sapiens (Human)
Function: Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane (PubMed:8420959). The channel adopts an open conformation at zero mV and a closed conformation at both positive and negative potentials (PubMed:8420959). There are two populations of channels; the main that functions in a lower open-state conductance with lower ion selectivity, that switch, in a voltage-dependent manner, from the open to a low-conducting 'closed' state and the other that has a normal ion selectivity in the typical high conductance, 'open' state (PubMed:8420959). Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol (PubMed:31015432). Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway (PubMed:31015432) Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane; the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion outer membrane. Membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P45880
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
103 |
GTEIAIEDQI C QGLKLTFDTT |
CCCCCCCCCC C CCCCCCHHHH |
1.87% |
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| 2 |
210 |
EFGGSIYQKV C EDLDTSVNLA |
CCCCCCCCCC C CCCCCCHHHH |
4.31% |
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| 3 |
227 |
VNLAWTSGTN C TRFGIAAKYQ |
CCCCCCCCCC C CCCCCCHHHH |
2.65% |
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| 4 |
47 |
LVKLDVKTKS C SGVEFSTSGS |
CCCCCCCCCC C CCCCCCHHHH |
4.35% |
22178444
2212679
20140087
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| 5 |
76 |
TGTLETKYKW C EYGLTFTEKW |
CCCCCCCCCC C CCCCCCHHHH |
2.23% |
22178444
18335467
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