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Sep. 10, 2014:
A total of 174 experimentally verified S-nitrosylation sites on 94 S-nitrosylated proteins from individualized human colorectal cancer tissues using a label-free quantitation strategy.

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Protein Name: Cofilin-2

UniprotKB/SwissProt ID: P45591 (P45591)

Gene Name: Cfl2

Organism: Mus musculus (Mouse)

Function: Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere

Other Modifications: View all modification sites in dbPTM

Protein Subcellular Localization: Nucleus matrix. Cytoplasm, cytoskeleton

Graphical Visualization of S-nitrosylation Sites:
InterPro ID Domain Name
IPR002108 ADF-H
IPR029006 ADF-H/Gelsolin-like_dom_sf
IPR017904 ADF/Cofilin

The S-nitrosylation sites of P45591

No. Position S-nitrosylated Peptide Secondary Structure of S-nitrosylated Peptide Solvent Accessibility of nitrosylated Site PubMed ID
1 39 IKKRKKAVLF C LSDDKRQIIV  CCCCCEECHH H HHHHCCCCCC  2.88% 21278135
2 80 SFVKLLPLND C RYALYDATYE  CCCCCEECHH H HHHHCCCCCC  3.31%