Protein Name:
Nicotinamide phosphoribosyltransferase
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UniprotKB/SwissProt ID: P43490 (P43490)
Gene Name:
NAMPT
Organism: Homo sapiens (Human)
Function: Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway. The secreted form behaves both as a cytokine with immunomodulating properties and an adipokine with anti-diabetic properties, it has no enzymatic activity, partly because of lack of activation by ATP, which has a low level in extracellular space and plasma. Plays a role in the modulation of circadian clock function. NAMPT-dependent oscillatory production of NAD regulates oscillation of clock target gene expression by releasing the core clock component: CLOCK-BMAL1 heterodimer from NAD-dependent SIRT1-mediated suppression (By similarity)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus. Cytoplasm. Secreted
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P43490
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
287 |
VSDSYDIYNA C EKIWGEDLRH |
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| 2 |
39 |
NTSKVYSYFE C REKKTENSKL |
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