Protein Name:
G protein-coupled receptor kinase 6
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UniprotKB/SwissProt ID: P43250 (P43250)
Gene Name:
GRK6
Organism: Homo sapiens (Human)
Function: Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Membrane
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Graphical Visualization of S-nitrosylation Sites:
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