Protein Name:
Matrin-3
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UniprotKB/SwissProt ID: P43243 (P43243)
Gene Name:
MATR3
Organism: Homo sapiens (Human)
Function: May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). May bind to specific miRNA hairpins (PubMed:28431233)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Nucleus matrix
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P43243
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
230 |
EDDRLRDGER C RDDSFFGETS |
CCHHHHHHHC C CCCCCCCCCC |
4.94% |
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| 2 |
552 |
REDAMAMVDH C LKKALWFQGR |
CCHHHHHHHC C CCCCCCCCCC |
5.29% |
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| 3 |
806 |
IPKTGFYCKL C SLFYTNEEVA |
CCHHHHHHHC C CCCCCCCCCC |
1.71% |
22178444
18335467
20140087
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| 4 |
821 |
TNEEVAKNTH C SSLPHYQKLK |
CCHHHHHHHC C CCCCCCCCCC |
2.52% |
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