Protein Name:
Excitatory amino acid transporter 2
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UniprotKB/SwissProt ID: P43006 (P43006)
Gene Name:
Slc1a2
Organism: Mus musculus (Mouse)
Function: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7557442, PubMed:7698742, PubMed:9373176). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (PubMed:9180080)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cell membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P43006
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
373 |
SAGTLPVTFR C LEDNLGIDKR |
CCCCCCCCCC C CEEEEEECCC |
4.22% |
22588120
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| 2 |
561 |
TLAANGKSAD C SVEEEPWKRE |
CCCCCCCCCC C CEEEEEECCC |
4.99% |
22588120
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