Protein Name:
3-ketoacyl-CoA thiolase, mitochondrial
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UniprotKB/SwissProt ID: P42765 (P42765)
Gene Name:
ACAA2
Organism: Homo sapiens (Human)
Function: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312)
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Mitochondrion
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P42765
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
107 |
QSIVNGCQEI C VKEAEVVLCG |
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| 2 |
116 |
ICVKEAEVVL C GGTESMSQAP |
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| 3 |
128 |
GTESMSQAPY C VRNVRFGTKL |
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| 4 |
179 |
AVKHKISREE C DKYALQSQQR |
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