Protein Name:
Caspase-2
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UniprotKB/SwissProt ID: P42575 (P42575)
Gene Name:
CASP2
Organism: Homo sapiens (Human)
Function: Is a regulator of the cascade of caspases responsible for apoptosis execution (PubMed:11156409, PubMed:15073321, PubMed:8087842). Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:15073321). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (PubMed:15073321) Acts as a positive regulator of apoptosis Acts as a negative regulator of apoptosis May function as an endogenous apoptosis inhibitor that antagonizes caspase activation and cell death
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization:
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P42575
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
343 |
DGKNHAGSPG C EESDAGKEKL |
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