Protein Name:
Epidermal growth factor receptor substrate 15
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UniprotKB/SwissProt ID: P42566 (P42566)
Gene Name:
EPS15
Organism: Homo sapiens (Human)
Function: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2
Other Modifications: View all modification sites in dbPTM
Protein Subcellular Localization: Cytoplasm. Cell membrane. Membrane, clathrin-coated pit. Early endosome membrane
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Graphical Visualization of S-nitrosylation Sites:
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The S-nitrosylation sites of P42566
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| No. |
Position |
S-nitrosylated Peptide |
Secondary Structure of S-nitrosylated Peptide |
Solvent Accessibility of nitrosylated Site |
PubMed ID |
| 1 |
586 |
EVTTAVTEKV C SELDNNRHSK |
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| 2 |
657 |
FKGSDPFASD C FFRQSTDPFA |
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| 3 |
824 |
SPKEKDPEIF C DPFTSATTTT |
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